Multimodal TAP-blockade analgesia is an effective component of ERAS protocols in colorectal surgery, providing adequate pain relief while minimizing the need for opioids and related side effects. Numerous clinical studies confirm the positive effect of TAP-blockade on early mobilization of patients, restoration of intestinal function and reduction of hospitalization time. This literature review examines strategies for optimizing multimodal analgesia within the framework of protocols for accelerated recovery after surgery on the colon and rectum (Enhanced Recovery After Surgery, ERAS). The necessity of using a multimodal approach to achieve adequate postoperative analgesia for elderly patients with comorbid pathology after colorectal interventions and to reduce the incidence of complications, reduce the duration of hospitalization and improve the postoperative quality of life of patients is substantiated. Special attention is paid to the role of ultrasound-controlled abdominal transverse blockade (TAP blockade) as a component of multimodal analgesia, which reduces the need for opioid analgesics and accelerates the restoration of gastrointestinal tract functions. The article presents current data on the efficacy and safety of TAP blockade in colorectal surgery, as well as prospects for the introduction and optimization of this method in clinical practice for elderly patients with comorbid pathology.